Freezing and Drying Biological Materials
نویسندگان
چکیده
منابع مشابه
The Effects on Biological Materials of Freezing and Drying by Vacuum Sublimation
A vacuum sublimation apparatus is described which will permit, (a) the removal of water from virus suspensions at temperatures ranging down to -80 degrees C., (b) continuous operation with a minimum of attention from the investigator, (c) sealing off of samples at operating pressures (10(-5) mm. Hg), (d) simultaneous lyophilization of aliquot samples at different temperatures, (e) isolation of ...
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With the increasing incidence of tuberculosis and drug resistant disease in developing countries due to HIV/AIDS, there is a need for vaccines that are more effective than the present bacillus Calmette-Guérin (BCG) vaccine. We demonstrate that BCG vaccine can be dried without traditional freezing and maintained with remarkable refrigerated and room-temperature stability for months through spray...
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A new technique based on freezing curve monitoring to quickly evaluate the viability of the biological materials subject to freezing or rewarming was established. A practical integrated device was fabricated which is simple in structure and cheap in price. Preliminary freezing experiments on the fresh fish blood demonstrated that minor changes in a biological material due to freezing or warming...
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Membranes are often damaged by freezing and/or dehydration, and this damage may be reduced by solutes. In many cases, these phenomena can be explained by the physical behavior of membrane-solute-water systems. Both solutes and membranes reduce the freezing temperature of water, although their effects are not simply additive. The dehydration of membranes induces large mechanical stresses in the ...
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MANY of the conventional types of freezing-drying apparatus employ an oil or mercury diffusion-pump, backed by a rotary pump, to obtain the high vacua necessary to ensure that the water molecules which escape from the specimens have sufficient mean free path to enable them to reach the vapour trap. Clearly, the efficiency of the freezing-drying process might be greatly increased if the specimen...
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ژورنال
عنوان ژورنال: Nature
سال: 1958
ISSN: 0028-0836,1476-4687
DOI: 10.1038/1811694a0